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acetonitrile and hydrogen cyanide ..

Friedberg KD, Schwarzkopf HA (1969) [The exhalation of hydrocyanic acid in cyanide poisoning.] , 24:235–242 (in German).

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stream from a hydrogen cyanide synthesis ..

A cross-sectional study was performed on the health effects of long-term cyanide exposure from a plating bath that contained 3% copper cyanide, 3% sodium cyanide, and 1% sodium chloride in the electroplating sections of three factories in Egypt that employed 36 male workers (non-smokers) with 5–15 years of experience; cyanide concentrations in the breathing zones of workers (15-min averaging time) ranged from 5 to 14 mg/m3, the averages in the three factories being 12, 7, and 9 mg/m3 at the time of the study. There was also exposure to petrol fumes, solutions of strong soap and alkalis, and hydrochloric acid. The exposed group reported symptoms such as headache, weakness, changes in taste and smell, giddiness, irritation of the throat, vomiting, effort dyspnoea, lacrimation, salivation, and precordial pain more frequently than controls. Twenty of the exposed workers (56%) exhibited thyroid enlargement to a mild or moderate degree. None of the workers had clinical manifestations of hypo- or hyperthyroidism, but the exposed group showed a lower uptake of radiolabelled iodine in the thyroid; there was no difference in the protein-bound 131I. The exposed workers had significantly higher haemoglobin and cyanomethaemoglobin values and lymphocyte counts compared with 20 male unexposed controls. Punctate basophilia of erythrocytes was present in 28 of 36 subjects (El Ghawabi et al., 1975). The contribution of the other exposures to the findings is difficult to discern.

Looking for quality and safe CAS.75-05-8 methyl cyanide synthesis acetonitrile

Hydrogen cyanide is principally produced by two synthetic catalytic processes involving the reaction of ammonia and natural gas (or methane) with or without air. It is also obtained as a by-product in the production of acrylonitrile by the ammoxidation of propylene, which accounts for approximately 30% of the worldwide production of hydrogen cyanide.

Acetonitrile (EHC 154, 1993) - IPCS INCHEM

Acetonitrile produces hydrogen cyanide when heated to decomposition or when reacted with acids or oxidizing agents (Reynolds, 1982).

Health hazard: acute acetonitrile poisoning with hydrocyanic acid slow, several hour incubation period. The main symptoms is weak, unable to, pale, nausea, vomiting, abdominal pain, diarrhea, chest tightness, chest pain, severe respiratory and circulatory system disorders, shallow breathing, slow and irregular, drop in blood pressure, pulse fine slow and, hypothermia, clonic convulsions and coma. Can have frequent micturition, urine protein.

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Ketenes were first studied as a class by Hermann Staudinger

Howard JW, Hanzal RF (1955) Chronic toxicity for rats of food treated with hydrogen cyanide. , 3:325–329.

Liquid cyanide compounds are easily absorbed through intact skin upon direct contact due to their lipid solubility and rapid epidermal penetration. Skin absorption of vapours of hydrogen cyanide is also possible when the air concentrations are high. The amount and rate of absorption of cyanides from aqueous solutions or atmospheric hydrogen cyanide depend upon the presence of moisture in the skin, concentration and pH of the solution, the surface area of contact, and the duration of contact (Dugard, 1987). studies with human skin have shown that penetration of sodium cyanide in aqueous solution through skin decreases with increasing pH (increasing dissociation), reflecting the more rapid absorption of the undissociated hydrogen cyanide. The permeability constant measured for the cyanide ion in aqueous solution was 3.5 × 10–4 cm/h, and that calculated for hydrogen cyanide was 1 × 10–4 cm/h (Dugard, 1987).

Hydrogen cyanide has a pa of 9.22; thus, at physiological pH (about pH 7), hydrocyanic acid is distributed in the body as hydrogen cyanide and is not present as the free cyanide ion. Hence, the form of cyanide to which exposure occurs, the salt or the free acid, does not influence distribution, metabolism, or excretion from the body (ECETOC, 2004). Inhaled or percutaneously absorbed hydrogen cyanide passes immediately into the systemic circulation. The distribution of cyanide to the various tissues is rapid and fairly uniform. Somewhat higher levels are generally found in the liver, lungs, blood, and brain. The tissue levels of hydrogen cyanide were 0.75, 0.42, 0.41, 0.33, and 0.32 mg/100 g of tissue in lung, heart, blood, kidney, and brain, respectively, in a man who died following inhalation exposure to hydrogen cyanide gas (Gettler & Baine, 1938; Ballantyne, 1983a; ATSDR, 1997; ECETOC, 2004). In contrast, high proportions of ingested sodium and potassium cyanide will pass through the liver and are detoxified by the first-pass effect.

Valade MP (1952) [Central nervous system lesions in chronic experimental poisoning with gaseous hydrocyanic acid.] , 136:280–225 (in French).
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  • Practice Questions | Biochemistry for Medics – Lecture Notes

    The invention is a method for reducing the hydrogen cyanide content of a synthesis ..

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    which lead simultaneously to the formation of hydrogen cyanide, acetonitrile, ..

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    Cyanide - Wikipedia

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Carboxylic acid - Synthesis of carboxylic acids | …

Groups of pregnant hamsters were fed diets consisting of two types of cassava meal, either a "low-cyanide" (sweet cassava meal) or a "high-cyanide" (bitter cassava meal) variety. These were mixed (80:20) with laboratory chow and administered on days 3–14 of gestation. The cyanide concentration of the sweet cassava meals was 0.6–0.7 mmol/kg; that of the bitter cassava meal was 5–11 (mean 7.9) mmol/kg. Cassava-fed dams gained significantly less weight than did control animals (fed diet similar in nutritional value as cassava, but without cyanogenic glycosides), and their offspring showed evidence of fetotoxicity (reduced fetal body weight and reduced ossification of sacrocaudal vertebrae, metatarsals, and sternebrae). The bitter cassava also produced a significant increase in the number of runts compared with litters from dams fed either low-protein or laboratory-stock diets. The only teratogenic effects noted were hydrocephalus in three animals in the low-cyanide (sweet cassava) test group and one encephalocoele found in one animal in the high-cyanide (bitter cassava) test group (Frakes et al., 1986b).

Practice Questions | Biochemistry for Medics – Lecture …

Pregnant Wistar rats (10 animals per group) were fed a cassava diet liberating 21 mg hydrogen cyanide/kg diet, fortified with 500 mg potassium cyanide/kg diet, throughout gestation and lactation. This is equivalent to an estimated daily dose of 16 mg cyanide/kg body weight. No effects were observed on the number, mortality at birth, or body weight of offspring or weight gain of pups during lactation (Tewe & Maner, 1981a).

Hydrogen cyanide | Wiki | Everipedia

As a respiratory poison, free cyanide (hydrogen cyanide or cyanide ion) has high acute toxicity due to its primary toxic effect of inhibiting cytochrome oxidase (by binding haem iron), the terminal enzyme of the mitochondrial electron transport chain (Isom & Way, 1974). Tissue utilization of oxygen is impaired, and, with time, a state of histotoxic anoxia occurs (oxidative metabolism is brought to complete cessation). Cyanide can also inhibit approximately 40 enzymes, including a number of other important metalloenzymes containing, for the most part, iron, copper, or molybdenum (e.g., alkaline phosphatase, carbonic anhydrase, catalase, peroxidase, ascorbic acid oxidase, xanthine oxidase, and succinic dehydrogenase); these reactions may also contribute to cyanide toxicity (Rieders, 1971; Ardelt et al., 1989; US EPA, 1990; ATSDR, 1997).

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