Advances in Solid-Phase Cycloadditions for Heterocyclic Synthesis.
Formation of N-branched oligonucleotides as by-products in solid-phase oligonucleotide synthesis
M., Solid-phase synthesis of C-terminally modified peptides.
The most common and commercially available BFC comprise esters (-nitrophenyl, pentafluorophenyl, -hydroxysuccinimide, sulfo--hydroxysuccinimide), isothiocyanates, maleimides, hydrazides, α-haloamides for the reaction with nucleophilic functional groups (-NH2, -SH, -OH) of vector molecules and formation of amide, urea, thiourea, Schiff-base, or thioester bond . Methods have been developed for the conjugation with peptides by solid-phase peptide synthesis (SPPS) resulting in defined position and number of chelate moieties. The outcome of the conjugation in solution wherein peptides and proteins comprise several reactive sites is very often a mixture of bioconjugate molecules with various content of the chelator. Such heterogeneity may cause the interpretation ambiguity of the performance of such imaging agents. Regioselective conjugation to antibodies was achieved by enzymatic reaction with lysine and glutamine residues using bacterial and human tissue transglutaminase as catalysts .
In brief, a molecular train is an assembly of an aptamer moiety on one end, serving as the locomotive, and tandem modules at the other end, serving as the boxcars by integrating the drug into phosphoramidites based on a solid-phase synthesis platform (Fig.
Oligo synthesis: Custom DNA oligonucleotides - …
Preparation, Characterization, and Application of Poly(vinyl alcohol)-graft-Poly(ethylene glycol) Resins: Novel Polymer Matrices for Solid-Phase Synthesis.
R.; Lober, S.; Hubner, H.; Gmeiner, P., Click chemistry on solid phase: parallel synthesis of -benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands.
DNA & RNA & ZNA Oligonucelotide Synthesis | …
321. Kiviniemi A, Makela J, Makila J, Saanijoki T, Liljenback H, Poijarvi-Virta P. . Solid-supported NOTA and DOTA chelators useful for the synthesis of 3'-radiometalated oligonucleotides. 2012;23:1981-8
Click Chemistry Publications - Scripps Research Institute
Reversed-Phase Column Selectivity Chart : Waters
R.; Herbertz, T., Solid/solution-phase annulation reagents: Single-step synthesis of cyclic amine derivatives.
Surface modification, functionalization and …
J., Trimethylsilyl-directed 1,3-dipolar cycloaddition reactions in the solid-phase synthesis of 1,2,3-triazoles.
1,2-Amino Alcohols and Their Heterocyclic Derivatives …
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