2-(Dimethylamino)ethyl methacrylate | C8H15NO2 - …
Synthesis and characterization of responsive poly(anionic liquid) microgels.
Faculty of Engineering Zhejiang University
Preparation, Characterization, and Application of Poly(vinyl alcohol)-graft-Poly(ethylene glycol) Resins: Novel Polymer Matrices for Solid-Phase Synthesis.
Surface-Initiated, Atom Transfer Radical Polymerization of Oligo(ethylene glycol) Methyl Ether Methacrylate and Subsequent Click Chemistry for Bioconjugation.
PDF Downloads : Oriental Journal of Chemistry
0.1% and 0.04% tretinoin is entrapped in MDS for topical treatment of acne vulgaris. This formulation uses patented methyl methacrylate/glycol dimethacrylate cross polymer porous microspheres to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. It has been marketed as Retin-A-Micro by Ortho-McNeil pharmaceutical 43. In a 21 day cumulative irritancy study and a split face study, microsponge formulation showed a reduced level of systemic absorption of tretinoin ranging from 25% - 40% reduction helping to explain the improved tolerability. Numerous studies have been conducted and published comparing the tolerability of various retinoids: tazarotene, Adapalene 44, 45, 46, 47, 48.
Fluconazole is an active agent against yeasts, yeasts like fungi and dimorphic fungi, with possible drawback of itching in topical therapy. Microsponges were prepared by liquid-liquid suspension polymerization of styrene and methyl methacrylate 52.
Methods of Synthesis of Nano- and Micrometric ..
The polymerization process leads to the formation of a reservoir type of system, which opens at the surface through pores. Impregnating them within preformed microsponges then incorporates the functional substances. Some times solvent may be used for faster and efficient incorporation of the active substances. Once the polymerization is complete the solid that result from the process are recovered from the suspension. The particles are then washed and processed until they are substantially ready for use. The microsponge product can be made using styrene and divinyl benzene or methyl methacrylate and ethylene glycol dimethacrylate as starting materials (Reaction vessel is shown in fig. 2).
Polymer / Monomer Composition: Polymer composition of the MDS can affect partition coefficient of the entrapped drug between the vehicle and the microsponge system and have direct influence on the release rate of entrapped drug. Release of drug from microsponge systems of different polymer compositions can be studied by plotting cumulative % drug release against time. The choice of monomer is dictated both by the vehicle into which it will be dispersed and characteristics of active ingredient to be entrapped. Various monomer combinations will be screened for their suitability with the drugs by studying their drug release profile. Release rate and total amount of drug released from the system composed of methyl methacrylate/ ethylene glycol dimethacrylate is slower than styrene/ divinyl benzene system. Polymers with varying electrical charges or degrees of hydrophobicity or lipophilicity may be prepared to provide flexibility in the release of active ingredients 25.
Scrivener Publishing journals: 2
Click Chemistry -- Publications
Journal of Nanoscience and Nanotechnology
Cellulose Chemistry and Technology
Nanocomposites: synthesis, structure, properties and new application opportunities
Cellulose Chemistry and Tehnology ..
Microsponge based Delivery System for Bio-Pharmaceuticals: The MDS is used for the delivery of biopharmaceuticals and in tissue engineering also. Newton D.W. has overviewed tissue targeted biopharmaceuticals delivery through microsponges 62. Bone-substitute compounds were obtained by mixing pre-polymerized powders of polymethyl-methacrylate and liquid methylmethacrylate monomer with two aqueous dispersions of a-tri calcium phosphate (a-TCP) grains and calcium-deficient hydroxyapatite (CDHA) powders. The final composites appeared to be porous and acted as microsponges 63, 64.
NOVEL APPROACH: MICROSPONGE DRUG DELIVERY …
Synthesis of Functionalized NMP Initiators for Click Chemistry: a Versatile Method for the Preparation of Functionalized Polymers and Block Copolymers.
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