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Synthesis of 1,3-Diols from Isobutene and HCHO via …

Synthesis of 1,3-Diols from Isobutene and HCHO via Prins Condensation-Hydrolysis Using ..

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the synthesis of 1,3-diols from ..

This well-planned cycloaddition enabled the execution of a concise and efficient diastereoselective route (24 steps @ 1.5% overall yield) that compared quite favorably with the others that had been reported at the time. The 2013 paper finished with the following paragraph (emphasis mine):

Chromium-catalyzed asymmetric synthesis of 1, 3-diols
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Maoecrystal V—as the advanced nature of its final letter implies—is one of a great many unusual terpinoids from the Chinese flowing plant Isodon eriocalyx.[1] It possesses a rather intricate and complex structure, a fact illustrated by the two decades that passed between its (first) isolation in 1994 and the successful determination of its structure in 2004—a long period indeed with modern spectroscopic techniques. Its dense, cage-like structure proved a tough nut to crack and another 5 years passed before the deluge of synthetic publications for this target began in 2009. The first total synthesis, reported somewhat controversially by the Yang group the following year, has only seemingly intensified the attention that it has received.

Stereocontrolled asymmetric synthesis of syn-E-1,4 …

Chromium-catalyzed asymmetric synthesis of 1, 3-diols Hong-Tao Ji a, Qing-Shan Tian b, ..
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That's right, for the first time in three and a half years' blogging I find myself writing about that rarest of publications: the collaborative total synthesis. Also somewhat unusually, the two US-based groups involved in the collaboration are both headed up by professors who originally hail from outside the States.[1]

So, if you've been reading the chemical literature much in the last 5 years or so, you've probably noticed the ongoing explosion of papers on the topic of Photoredox chemistry. It seems that organic chemists in the field have been borrowing increasingly bizarre transition metal complexes from the electroluminescence, photophysical and materials literature for some time now, and keeping track of them all is a real pain. I mean, how many people can draw from memory the structure of that Bernhard Ir(4',6'-dF-5-CF3-ppy)2(4,4'-dtbbpy)PF6 catalyst from the latest MacMillan group paper? Don't look at me like that—it's commercially available from Aldrich.[1] And you can remember its oxidation potential, right? Versus the ? In the Ir(iii)* excited state and as Ir(iv) after reductive quenching?

Asymmetric Synthesis of 2-Amino-1,4-diols (1988) | …

1,5-HEXADIENE-3,4-DIOL (MIXTURE OF DL- AND MESO …
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Given the wide occurrence of this type of molecular skeleton in natural products and biologically active compounds, further improvements for preparation of 1, 3-diols derivatives with high enantioselectivity under mild reaction conditions are highly desired. In the past two years, we have been interested in chromium-catalyzed reactions and have focused on the development of carbazole-based bisoxazolines in asymmetric transformations [-]. As a continuation of our previous research, herein we reported a highly enantioselective chromium-catalyzed allylation of aldehydes to provide 1, 3-diols derivatives under mild reaction conditions. This method provides a complementary and a more practical strategy for the synthesis of 1, 3-diols with tolerance of a broad range of functional groups.

Initially, we tested the reaction of ()-(((4-bromobut-2-en-1-yl) oxy)methyl)benzene (1a) and 5-chloropentanal (2a) with 10 mol% of chromium(Ⅱ) chloride in DME at room temperature, and the desired product 3a was obtained in 46% yield (, entry 1). Delightfully, when the chiral carbazole ligand (L1) was used, the product 3a was obtained in even better yield (75%) and high enantioselectivity (90% ) (, entry 2). Solvent screening showed that THF was better than DME (, entry 3). It was found that the temperature is an important influential factor for the enantioselectivity of this reaction, when the reaction temperature lowered down to -10 ℃, the product 3a was obtained in 96% ( entry 4). The temperature lowered further to -20 ℃, the enantioselectivity remained the same but the yield decreased (56%) (, entry 5). The effects of a variety of chiral ligands in the reaction system were also tested. When ligand L2 and L3 were used as ligands in this reaction, comparable and moderate enantioselectivities were obtained, however, the yields were decreased to 38% and 23% respectively (, entries 6-7).

23/11/2011 · Stereocontrolled asymmetric synthesis of syn-E-1,4-diol-2-enes using allyl boronates ..
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  • Sulfide synthesis by S-alkylation or 1,4-addition

    Diol - Wikipedia

  • Diol synthesis by dihydroxylation - Organic chemistry

    Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

  • Dihydroxylation of alkenes with cold, dilute KMnO4 to …

    Categories: C-S Bond Formation > Synthesis of sulfides (thioethers) and derivatives

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Quinine total synthesis - Wikipedia

For example, a 2000 MW conventional PPG diol has a monol content of about 0,03 meq/g, which correspond to a functionality of 1,92, whereas, a 4000 MW PPG diol has a monol content of about 0.085 meq/g and functionality of only 1.7.

B.R.S.M — An organic chemistry blog

The new generation of ultra low monol content polyols has a typical monol (insaturation) content of 0.005 meq/g or less, which correspond to a functionality of 1.98 for a 4000 MW diol.

Tuscany Diet - Biochemistry and Nutrition

As the name implies, crotogoudin is another natural product from the goldmine of bioactive compounds that is the Croton genus of flowering trees. Seeds of these plants have been used for hundreds of years to produce the famous , a violent emetic and purgative used in early medicine across the globe before anyone realised just how bad it really was. Now, the notorious extract is mostly used as a source of various natural products, a reproducible way of inducing pain and/or irritation in animal experiments and a case in point that things described as 100% natural can still be extremely bad for you. It also serves as the major source of the important natural product , and gave its name to crotonic and tiglic acid (and thus crotonaldehyde).[1] Along with a number of other natural products isolated from this genus, crotogoudin displays promising cytotoxic activity, which, coupled with the rare 3,4-seco atisane skeleton, was probably one of the reasons that the Carreira group recently embarked on its total synthesis.

⇑ Back to the top ⇑ Regulation of gluconeogenesis

It is well known that base catalyzes not only the addition of propylene oxide to the growing polyol molecule, but also a side reaction in which propylene oxide isomerizes to allyl alcohol (Figure 1.24).

20/12/2017 · Synthesis of homochi..

With the optimized reaction conditions in hand, the substrate scope was promptly investigated. Firstly, we checked the reaction of ()-(((4-bromobut-2-en-1-yl)oxy)methyl)benzene (1a) with various aldehydes; the representative aliphatic aldehydes, such as capronaldehyde and 3-phenylpropanal, reacted efficiently under this reaction conditions and the products 3b and 3c were obtained with high enantioselectivity (93% and 95% ) and in moderate yields (). It was noted that naturally occurring aldehyde, citronellal was also a good substrate under this reaction condition and gave 3d in 87% yield with 95% . Aromatic aldehydes, such as benzaldehyde and 3-fluoro-benzaldehyde, reacted with 1a to afford the products 3e and 3f with 90% and 91% . Reactions of the cinnamaldehyde and its derivatives with electron-withdrawing groups and electron-donating groups on the aromatic ring also proceeded smoothly to furnish a range of desired 1, 3-diol products 3g-3i in moderate yield with high enantioselectivity (96%-98% ). 2-Thenaldehyde was converted to 3j under the standard condition to give a good isolated yield (73%) and a high enantioselectivity (91% ). We were pleased to find that benzyl protection could be replaced with TBDPS group. The coupling of the latter with four aliphatic aldehydes proceeded equally well in terms of efficiency and enantioselectivity, as the corresponding 3k-3n were obtained with high values and in comparable yields.

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