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Sreedharan SP, Patel DR, Huang JX andGoetzl EJ: Cloning and functional expression of a humanneuroendocrine vasoactive intestinal peptide receptor. BiochemBiophys Res Commun. 193:546–553. 1993. : :
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Vandermeers A, Vandenborre S, Hou X, deNeef P, Robberecht P, Vandermeers-Piret MC and Christophe J:Antagonistic properties are shifted back to agonistic properties byfurther N-terminal shortening of pituitaryadenylate-cyclase-activating peptides in human neuroblastomaNB-OK-1 cell membranes. Eur J Biochem. 208:815–819. 1992. :
Lelièvre V, Pineau N, Du J, Wen CH, NguyenT, Janet T, Muller JM and Waschek JA: Differential effects ofpeptide histidine isoleucine (PHI) and related peptides onstimulation and suppression of neuroblastoma cell proliferation. Anovel VIP-independent action of PHI via MAP kinase. J Biol Chem.273:19685–19690. 1998.
Custom Peptide Synthesis - New England Peptide
Tsukada T, Horovitch SJ, Montminy MR,Mandel G and Goodman RH: Structure of the human vasoactiveintestinal polypeptide gene. DNA. 4:293–300. 1985.
Valdehita A, Bajo AM, Schally AV, VargaJL, Carmena MJ and Prieto JC: Vasoactive intestinal peptide (VIP)induces transactivation of EGFR and HER2 in human breast cancercells. Mol Cell Endocrinol. 302:41–48. 2009. : :
Peptide Synthesis - Peptide Protein Research (PPR Ltd)
Custom synthesis of synthetic peptides and peptide based molecules
This phenomenon has been attributed to the self-association of the peptide chain by formation of hydrogen bonds .
Antibody Service - Polyclonal Antibody | Peptide Synthesis
This modified amino acid is obtained when synthesizing peptides with C-terminal Cys.
Peptide Sequencing and Synthesis - WWW Project Top …
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Sherwood NM, Krueckl SL and McRory JE: Theorigin and function of the pituitary adenylate cyclase-activatingpolypeptide (PACAP)/glucagon superfamily. Endocr Rev. 21:619–670.2000.
ChemPep - Peptide Synthesis, Peptide Array, HATU, …
Piper PJ, Said SI and Vane JR: Effects onsmooth muscle preparations of unidentified vasoactiv peptides fromintestine and lung. Nature. 225:1144–1146. 1970. : :
Custom Peptide Synthesis - Biopeptide Co., Inc.
Garanger E, Boturyn D and Dumy P: Tumortargeting with RGD peptide ligands-design of new molecularconjugates for imaging and therapy of cancers. Anticancer AgentsMed Chem. 7:552–558. 2007. : :
Basic Peptides synthesis introduction - LifeTein®
The base catalyzed elimination of the suffhydryl protecting group affords dehydroalanine and the subsequent addition of piperidine yields the C-terminally modified peptide . This side reaction is minimized (but not avoided!) when trityl is used for the protection of the C-terminal Cys.
PolyPeptide Group - Peptides, Peptide Synthesis and …
Wei Y and Mojsov S: Tissue specificexpression of different human receptor types for pituitaryadenylate cyclase activating polypeptide and vasoactive intestinalpolypeptide: implications for their role in human physiology. JNeuroendocrinol. 8:811–817. 1996. :
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Several examples of aspartimide formation during the peptide elongation have been reported, together with the reopening of the aspartimide cycle during the subsequent Fmoc deprotection step, yielding piperidides [64,65,66].
Microwave Peptide Synthesis - CEM
Diketopiperazine formation may be circumvented in Fmoc/tBu SPPS
- by using 2-chlorotrityl chloride resin or other bulky resins such as DHPP-Resin.
- by coupling the appropriate Fmoc-dipeptide in lieu of the penultimate amino acid. In that case a risk of epimerization exists if the C-terminal amino acid of this dipeptide is not Gly or Pro.
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